Yes, Very few individual human genomes have been fully sequenced
They are those of J. Craig Venter, a pioneer of DNA decoding; James D. Watson, the co-discoverer of the DNA double helix; two Koreans; a Chinese; a Yoruban; and a leukemia victim. Dr. Quake’s seems to be the eighth full genome, not counting the mosaic of individuals whose genomes were deciphered in the Human Genome Project.
In following thread at friendfeed Neil Saunders also suggested that arguably none have been “fully” sequenced, since there are still gaps. Forget about accuracy of sequenced individual human genomes, despite all efforts and claims only 92.3% of the human genome has been completed, number of regions of the human genome such as centromeres, telomeres, several loci are considerably unfinished. No doubt these regions are difficult to sequence using current technology. Further, Daniel MacArthur of Genetic future blog tweets,
the “only 8 human genomes have been fully sequenced” meme going round, it’s crap: that’s just the number that have been PUBLISHED.
May be he is correct in his observation that eight is the number of published individual human genomes and not the exact number of individual human genomes sequenced completely. Seems like the number may be bigger than eight assuming a lot of remained unpublished, but why one will not publish especially when we know individual genomes are major attraction for top journals like Nature, Science and not to mention the media publicity. May be eight is not correct figure and it really does not matter if it is eight or ten or more, even if same individual genome was sequenced twice. It matters because we are talking about personalized medicine and democratizing genomics, but are we there yet?
Presumably once the 1000 genomes project is complete then we have a 1000
. Without saying who and how, I know of at least three more unpublished ones.
Yes, Very few individual human genomes have been fully sequenced: Can someone please enlighten me what is the ex.. http://bit.ly/16zBKX
The number of complete human genomes sequenced is far higher than that. The “1000 genomes” project is now spitting two genomes a day. Of course I am talking of only 1X. Furthermore, this is high-speed sequencing, and therefore the accuracy is much lower. And we are no talking of assembled, annotated genomes. But still. Gattaca is here. One rough genome sequence can now be obtained in a few hours for a cost of a few hundreds dollars … provided you invested a few millions in a sequencing centre
In the next year, there should be at least 150 more genomes sequenced (specifically “cancer genomes”) by The Genome Center at Washington University. See a write up from one of my colleagues: http://bit.ly/18rcL3